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How automotive exec Crystal Brown founded CircNova, an AI drug discovery biotech | TechCrunch

Feb 21, 2025 - techcrunch.com
Tiny Michigan biotech startup CircNova has raised a $3.3 million seed round to advance its AI-driven technology targeting circular RNA, a promising new method for developing therapies for conditions lacking drug treatments. Co-founded by CEO Crystal Brown, who transitioned from the automotive industry to biotech, CircNova utilizes a proprietary AI engine, NovaEngine, to identify and produce novel circular RNAs. This technology, developed in collaboration with the University of Michigan, aims to address complex health issues like ovarian cancer and neurodegenerative diseases. The startup's approach is based on the work of co-founder Joe Deangelo, with investor William Grenawitzke as the third co-founder.

Brown's unconventional path to biotech began when she left a successful automotive career to work in life sciences, eventually leading to her first startup, which failed but built her reputation in Michigan's startup community. Encouraged by VCs, she co-founded CircNova with Deangelo in May 2023, initially using small grants to develop the startup's processes and secure a patent application. The $3.3 million seed round, led by South Loop Ventures and supported by several other investors, reflects confidence in Brown's resilience and the potential of CircNova's innovative approach.

Key takeaways:

  • CircNova, a Michigan biotech startup, raised $3.3 million in seed funding to develop AI technology targeting circular RNA for new therapies.
  • Co-founder and CEO Crystal Brown transitioned from the automotive industry to biotech, overcoming initial setbacks to establish CircNova.
  • CircNova's proprietary AI engine, NovaEngine, predicts circular RNA structures and collaborates with the University of Michigan for validation.
  • The seed round was led by South Loop Ventures and included investments from several other venture capital firms.
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