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New AI generates CRISPR proteins unlike any seen in nature

May 19, 2024 - freethink.com
Berkeley-based startup Profluent has developed an AI platform that can generate millions of CRISPR-like proteins, opening the door to gene editors with capabilities beyond what has been found in nature. The platform, likened to ChatGPT for genetic technology, allows scientists to leverage AI-designed gene editors to advance their research. The company has also made a new CRISPR system, OpenCRISPR-1, open source, enabling it to be used for ethical research or commercial use.

Profluent recently announced that it had successfully used OpenCRISPR-1 to edit human DNA, a breakthrough that the company's CEO, Ali Madani, described as a "scientific moonshot". The company plans to use feedback to further optimize OpenCRISPR-1 and establish partnerships with research institutions and drug developers interested in creating custom AI-designed CRISPR proteins. Madani believes that this marks a significant step towards a future where AI can be used to design bespoke treatments and cures for patients in need.

Key takeaways:

  • Profluent, a Berkeley-based startup, has trained an AI to generate new, never-before-seen CRISPR proteins, potentially expanding the capabilities of gene editors.
  • The company is making a new CRISPR system, OpenCRISPR-1, open source, allowing scientists to leverage an AI-designed gene editor for their research.
  • OpenCRISPR-1 has been successfully used to edit human DNA, marking a significant breakthrough in the field.
  • Profluent plans to further optimize OpenCRISPR-1 based on feedback, and is looking to establish partnerships with research institutions and drug developers for creating custom AI-designed CRISPR proteins.
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